Curriculum vitae

Education

Johns Hopkins University School of Medicine, Baltimore, MD

McKusick-Nathans Institute of Genetic Medicine

Doctor of Philosophy in Human Genetics and Molecular Biology, 2011 – 2017

National Science Foundation (NSF) Graduate Research Fellow Link 2

North Carolina State University, Raleigh, NC

Bachelor of Science in Biochemistry, Minor in Genetics, 2007 – 2011

Summa Cum Laude, Barry M. Goldwater Scholar Link 2

Research Experience

AHA SFRN Postdoctoral Fellow, 6/2018-ongoing

Laboratory of Svati H Shah, MD, MHS

Duke Molecular Physiology Institute, Durham, NC

Postdoctoral Fellow, 1/2017-6/2018

MassGeneral Institute for Neurodegenerative Disease (MIND) Informatics group

Massachusetts General Hospital and Harvard Medical School, Cambridge, MA

Graduate Student, 8/2011 – 1/2017

Laboratory of Dan E Arking, PhD

McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD

Rotation Student, 8/2011 – 12/2011

Laboratory of Nicholas Marsh-Armstrong, PhD

Hugo W Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD

Undergraduate Student, 5/2008 – 7/2011

Laboratory of Robert G Franks, PhD

Department of Genetics, North Carolina State University, Raleigh, NC

Skills

Notable Software and Programming Languages

R Perl Python
Java Bash IGV
Plink Impute2 ShapeIT
DEPICT Eigenstrat Epacts
FAST R-seqMeta R-survival
METAL RAREMETAL OpenGridEngine
Affymetrix Power Tools⁣⁣ NCBI SRA Toolkit Tensorflow

Notable Molecular Biology Techniques

Dissection of optic nerve Cryosectioning
in situ Hybridization FISH with Mito DNA
TUNEL assay Immunohistochemistry
Protein in vitro expression⁣⁣ Protein-protein interaction assays
Protein Solubilization Phenotypic Analysis
Western Plotting Affinity Chromatography
Sub-cloning E. coli Culturing and Induction
Yeast 2-Hybrid Oligo Design
Confocal Microscopy PCR Amplification
Bimolecular Fluorescence Complementation (BiFC)

Publications

Bihlmeyer NA, Merrill E, Lambert Y, Srivastava GP, Clark TW, Hyman BT, et al. Novel methods for integration and visualization of genomics and genetics data in Alzheimer’s disease. Alzheimers Dement. 2019;15: 788–798. doi:10.1016/j.jalz.2019.01.011 PMCID: PMC6664293

Hopp SC, Bihlmeyer NA, Corradi JP, Vanderburg C, Cacace AM, Das S, et al. Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain. J Neurochem. 2018;147: 24–39. doi:10.1111/jnc.14469 PMCID: PMC6181788

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, et al. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biol. 2018;19: 87. doi:10.1186/s13059-018-1457-6 PMCID: PMC6048820

Roselli C, Chaffin MD, Weng L-C, Aeschbacher S, Ahlberg G, Albert CM, et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018;50: 1225–1233. doi:10.1038/s41588-018-0133-9 PMCID: PMC6136836

Lin H, van Setten J, Smith AV, Bihlmeyer NA, Warren HR, Brody JA, et al. Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval. Circ Genom Precis Med. 2018;11: e002037. doi:10.1161/CIRCGEN.117.002037 PMCID: PMC5951629

Bihlmeyer NA, Brody JA, Smith AV, Warren HR, Lin H, Isaacs A, et al. ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Circ Genom Precis Med. 2018;11: e001758. doi:10.1161/CIRCGEN.117.001758 PMCID: PMC5992491

Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, et al. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 2017;49: 946–952. doi:10.1038/ng.3843 PMCID: PMC5585859

Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, et al. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017;28: 981–994. doi:10.1681/ASN.2016020131 PMCID: PMC5328154

van den Berg ME, Warren HR, Cabrera CP, Verweij N, Mifsud B, Haessler J, et al. Discovery of novel heart rate-associated loci using the Exome Chip. Hum Mol Genet. 2017;26: 2346–2363. doi:10.1093/hmg/ddx113 PMCID: PMC5458336

Lubitz SA, Brody JA, Bihlmeyer NA, Roselli C, Weng L-C, Christophersen IE, et al. Whole Exome Sequencing in Atrial Fibrillation. PLoS Genet. 2016;12: e1006284. doi:10.1371/journal.pgen.1006284 PMCID: PMC5010214

Busby B, Lesko M, August 2015 and January 2016 Hackathon participants, Federer L. Closing gaps between open software and public data in a hackathon setting: User-centered software prototyping. F1000Res. 2016;5: 672. doi:10.12688/f1000research.8382.2 PMCID: PMC4837979

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, et al. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun. 2015;6: 5897. doi:10.1038/ncomms6897 PMCID: PMC4311266

Bihlmeyer NA, Brody JA, Smith AV, Lunetta KL, Nalls M, Smith JA, et al. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014;15: 159. doi:10.1186/s12863-014-0159-7 PMCID: PMC4301661

Davis CO, Kim K-Y, Bushong EA, Mills EA, Boassa D, Shih T, et al. Transcellular degradation of axonal mitochondria. Proc Natl Acad Sci USA. 2014;111: 9633–9638. doi:10.1073/pnas.1404651111 PMCID: PMC4084443

Conferences

Oral Presentations

Bihlmeyer, Nathan A. et al. “Investigating the effects of coding variants on QT and JT intervals utilizing data from 95,626 individuals” American Society of Human Genetics Annual Meeting (2015). Link 2

Bihlmeyer, Nathan A. et al. “Characterization of Physical Interactions within a Multimeric Transcriptional Corepressor Complex in ArabidopsisFourth Annual Atlantic Coast Conference Meeting of the Minds Conference (2009). Link 2

Poster Presentations

Bihlmeyer, Nathan A. et al. "Imputation of plasma metabolites using whole exome sequencing data." American Society of Human Genetics Annual Meeting (2019).

Bihlmeyer, Nathan A. et al. "Metabolic pathways and obesity interventions." American Heart Association Children's Strategically Focused Research Network Annual Meeting (2019).

Bihlmeyer, Nathan A. et al. "Metabolite Pathways in Pediatric Obesity Interventions." American Heart Association Children's Strategically Focused Research Network Annual Meeting (2018).

Bihlmeyer, Nathan A. et al. “Genetic Diversity is a Predictor of Survival in Humans.” American Society of Human Genetics Annual Meeting (2013).

Bihlmeyer, Nathan A. et al. “Whole Genome Heterozygosity as a Predictor of Longevity.” 6th Annual Symposium and Poster Session on Genomics and Bioinformatics by the Center for Computational Genomics at Johns Hopkins (2012).
Presentation was awarded “Best poster in the category of biology.”

Bihlmeyer, Nathan A. et al. “Exploration of Transcriptional Control Pathways Involving SEUSS in Arabidopsis thaliana.” State of North Carolina Undergraduate Research and Creativity Symposium (2010).

Bihlmeyer, Nathan A. et al. “Bimolecular Fluorescence Complementation as a Method to Study Transcriptional Regulatory Complexes.” North Carolina State University’s Annual Genetics Department Retreat (2010).
Presentation was awarded “Potential to be Great Award.”

Involvement

2019

2018

2017

2015

2014

2013

2012

Undergraduate Activities and Societies

Honors

2018

2011

2010

2009

2006

(Updated: Mon, 10 Feb 2020 15:30:44 -0500)