Curriculum vitae
Education
Johns Hopkins University School of Medicine, Baltimore, MD
McKusick-Nathans Institute of Genetic Medicine
Doctor of Philosophy in Human Genetics and Molecular Biology, 2011 – 2017
National Science Foundation (NSF) Graduate Research Fellow Link 2
North Carolina State University, Raleigh, NC
Bachelor of Science in Biochemistry, Minor in Genetics, 2007 – 2011
Summa Cum Laude, Barry M. Goldwater Scholar Link 2
Research Experience
Postdoctoral Fellow, 6/2018-12/2022
Laboratory of Svati H Shah, MD, MHS
Duke Molecular Physiology Institute, Durham, NC
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American Heart Association (AHA) Strategically Focused Research Networks (SFRN) Fellow
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National Human Genome Research Institute (NHGRI) T32 Scholar in Genomic Medicine
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Researched molecular pathways and biomarkers of obesity and exercise intervention efficacy across the lifespan in the Hearts-and-Parks, POMMS, WLM, STRRIDE-PD and CATHGEN cohorts, using advanced computational techniques for integrated omics analysis
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Led a multidisciplinary, multi-center team to identify novel metabolic and proteomic pathways in obesity and insulin resistance
Postdoctoral Fellow, 1/2017-6/2018
MassGeneral Institute for Neurodegenerative Disease (MIND) Informatics group
Massachusetts General Hospital and Harvard Medical School, Cambridge, MA
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Massachusetts Center for Alzheimer Therapeutics Science (MassCATS) Fellow
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Integrated multi-omic data in an effort to discover novel molecular targets in Alzheimer disease therapeutics
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Worked on multi-omics data visualization in ROSMAP, Mount Sinai Brain Bank (MSBB), and Mayo Clinic Brain Bank (MCBB) human cohorts; and International Genomics of Alzheimer's Project (IGAP) meta-analysis
Graduate Student, 8/2011 – 1/2017
Laboratory of Dan E Arking, PhD
McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD
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Elucidated genetic determinants of heart disease and longevity through genome-wide association analyses in ARIC, PROSe-ICD, and DISCERN human cohorts
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Studied the genetics of electrical conduction, focusing on the role both rare and common genetic variants
Rotation Student, 8/2011 – 12/2011
Laboratory of Nicholas Marsh-Armstrong, PhD
Hugo W Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD
Undergraduate Student, 5/2008 – 7/2011
Laboratory of Robert G Franks, PhD
Department of Genetics, North Carolina State University, Raleigh, NC
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Determined how the SEUSS family of transcriptional regulators affects the carpel margin meristem, the meristem that gives rise to seeds, in Arabidopsis thaliana
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Performed biochemical assays with bacterially expressed fusion proteins
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Conduced independent research in gene regulation and design of experiment protocols
Skills
Expertise in Diverse in Multi-Omic Analyses
Genomics
NextGen-seq (NGS) including whole exome (WES) and genome (WGS) sequencing
Illumina and Affymetrix genotyping arrays for common and rare variants
Imputed-genotypes
Transcriptomics
RNA-seq
Affymetrix microarray
Proteomics
Olink platform
Mass spectrometry-based
Targeted ELISA
Metabolomics
Mass spectrometry-based nontargeted and targeted (Broad Institute and Duke versions)
Biocrates platform
Microbiomics
16S Metagenomics
Clinical Labs and Surveys
Proficient in Software and Programming Languages
| R | Perl | Python |
| Java | Bash | Linux |
| Plink (1.07, 1.9, and 2) | Impute2 | ShapeIT |
| DEPICT | Eigenstrat | Epacts |
| FAST | R-seqMeta | R-survival |
| METAL | RAREMETAL | FaST-LMM |
| Bowtie (2) | TopHat (2) | Cufflinks (2) |
| Affymetrix Power Tools | NCBI SRA Toolkit | IGV |
| Open Grid Engine | Slurm | IBM Platform LSF |
| Docker | Kubernetes | Openshift |
| Machine Learning | Tensorflow | Keras |
| Scikit-learn | Python-pandas | R-phyloseq |
History of work using Molecular Biology Techniques
| Dissection of optic nerve | Cryosectioning |
| in situ Hybridization | FISH with Mito DNA |
| TUNEL assay | Immunohistochemistry |
| Protein in vitro expression | Protein-protein interaction assays |
| Protein Solubilization | Phenotypic Analysis |
| Western Plotting | Affinity Chromatography |
| Sub-cloning | E. coli Culturing and Induction |
| Yeast 2-Hybrid | Oligo Design |
| Confocal Microscopy | PCR Amplification |
| Bimolecular Fluorescence Complementation (BiFC) | |
Conferences
Oral Presentations
Bihlmeyer NA, et al. Investigating the effects of coding variants on QT and JT intervals utilizing data from 95,626 individuals. American Society of Human Genetics Annual Meeting 2015. Link 2
Bihlmeyer, NA, et al. Characterization of Physical Interactions within a Multimeric Transcriptional Corepressor Complex in Arabidopsis. Fourth Annual Atlantic Coast Conference Meeting of the Minds Conference 2009. Link 2
Poster Presentations
Bihlmeyer, NA, et al. Pediatrics and proteins: Unique biology of children undergoing obesity intervention. NHGRI Annual Training & Career Development Meeting 2022.
Bihlmeyer, NA, et al. Pediatrics and proteins: Molecular discovery in the Hearts & Parks study of children with obesity. American Society of Human Genetics Annual Meeting 2021.
Bihlmeyer, NA, et al. Omic profiling identifies complex lipid species and metabolism-related proteins associated with response to weight loss interventions. American Society of Human Genetics Annual Meeting 2020.
Involvement
2022
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Talk given at the Duke Genomic and Precision Medicine forum entitled, “Pediatrics and proteins: Biology and biomarkers of early cardiovascular health (CVH)”: Durham, NC, May
2021
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Presented at the Duke Pediatric Obesity Microbiome & Metabolism Study NIDDK R24 Annual External Advisory Committee Meeting: Durham, NC, April
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Talk given at the Duke Genomic and Precision Medicine forum entitled, “Pediatrics, Proteins and Poop: Molecular Discovery in the Hearts & Parks Study of Children with Obesity”: Durham, NC, May
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Attended the Duke GCB Academy’s course: Fundamentals of Mass Spectrometry for Proteomics by Arthur Moseley, PhD: Durham, NC, June
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Reported for the Duke branch at the American Heart Association Children's Strategically Focused Research Networks Annual Meeting: Virtual, September
2020
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Presented at the Duke Pediatric Obesity Microbiome & Metabolism Study NIDDK R24 Annual External Advisory Committee Meeting: Durham, NC, September
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Reported for the Duke branch at the American Heart Association Children's Strategically Focused Research Networks Annual Meeting: September
2019
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Selected for Duke Early Career Grant Program: Durham, NC, July
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Attended the Duke Machine Learning Summer School: Durham, NC, June
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Talk given at the DMPI Works-in-Progress Series entitled, “Computational Approaches to Understanding Metabolic Pathways of Obesity in Adult and Childhood”: Durham, NC, June
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Became COnsortium of METabolomics Studies (COMETS) Affiliate Member: April
2018
2017
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Attended the RECOMB/ISCB Conference on RegSysGen with DREAM: New York City, NY, November
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Attended the Massachusetts Open Cloud Third Annual Workshop: Boston, MA, October
2015
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Selected for the National Center for Biotechnology Information (NCBI) Hackathon: Bethesda, MD, August Link 2
2014
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Attended the Genomics of Common Diseases (GCD) Conference: Potomac, MD, September
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Teaching Assistant of Introduction to Computational Genetics Course at Johns Hopkins University: Baltimore, MD
2012
Undergraduate Activities and Societies
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National Society of Collegiate Scholars
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North Carolina State University Presidents’ Round Table
Honors
2020
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National Human Genome Research Institute (NHGRI) T32 Scholarship in Genomic Medicine
2018
2011
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National Science Foundation Graduate Research Fellowship Link 2
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The H. Robert Horton Award for Outstanding Undergraduate Achievement in Biochemistry
2010
2009
2006
(Updated: Thu, 28 Mar 2024 15:17:15 -0400)
